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Showing posts from September, 2018

Ketones and Autism Part 4 � Inflammation, Activated Microglia, CtBP, the NLRP3 Inflammasome and IL-1�

This series of posts on ketones and the ketogenic diet (KD) is nearly finished and I am glad that I made favourable comments about the KD earlier on in this blog, before I knew all the nitty-gritty of the science. (no re-editing required)



Inflammasome Inhibition: Putting Out the Fire
Ketones and Autism Part 1 - Ketones, Epilepsy, GABA and Gut Bacteria Ketones and Autism Part 2 - Ketones as a Brain Fuel to treat Alzheimer�s, GLUT1 Deficiency and perhaps more Ketones and Autism Part 3 - Niacin Receptor HCA2/GPR109A in Autism, Colonic Inflammation, Psoriasis and Multiple Sclerosis
There is more than one anti-inflammatory mechanism involved in the ketogenic diet (KD); in Part 3 we covered Niacin Receptor HCA2, today in Part 4 we look at NLRP3 and CtBP. The reason I am going into all this detail is because if you knew why someone responds to ketones in a favourable way, there might actually be an even more potent therapy using an entirely different substance. CtBP represses the transcription of c…